- ￥1350 - 3000
- Proteintech
- 10170-1-AP
- 2025年10月13日
- WB, IHC, ELISA
- Rabbit
- human, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human CFB protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, IHC, ELISA
- 靶点：
Complement factor B
- 抗体英文名：
Complement factor B Polyclonal antibody
- 抗体名：
Complement factor B Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | human plasma, human blood, rat plasma |
| Positive IHC detected in | human liver tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| Immunohistochemistry (IHC) | IHC : 1:200-1:800 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
10170-1-AP targets Complement factor B in WB, IHC, IF, ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, IHC, ELISA |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, rat |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag0226 Product name: Recombinant human CFB protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 574-762 aa of BC007990 Sequence: DYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLG |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | complement factor B |
| 别名 | CFB, Complement factor B Ba fragment, CFAB, C3/C5 convertase, BFD |
| 计算分子量 | 86 kDa |
| 观测分子量 | 93-100 kDa, 60-69 kDa |
| GenBank蛋白编号 | BC007990 |
| 基因名称 | Complement factor B |
| Gene ID (NCBI) | 629 |
| RRID | AB_2082384 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P00751 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Complement factor B (CFB) is a component of the alternative pathway of complement activation. Complement factor B is a 93-100 kDa glycoprotein and is cleaved into Ba (33 kDa) and Bb (60 kDa) by factor D in the presence of C3b (PMID: 11025450). The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This antibody raised against 573-761aa of human complement factor B can recognize complement factor B and Bb fragment.
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文献和实验| Species | Application | Title |
|---|---|---|
| human,mouse | IF | Nat Commun The classical pathway triggers pathogenic complement activation in membranous nephropathyAuthors - Larissa Seifert |
| human | WB | J Cell Physiol IL-1/IL-1R signaling induced by all-trans-retinal contributes to complement alternative pathway activation in retinal pigment epithelium.Authors - Xinxuan Cheng |
| human | WB,IHC,IF | Cell Oncol (Dordr) Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.Authors - Reiri Shimazaki |
| human | WB | Br J Cancer Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.Authors - Yanxia Jin |
| human,mouse | WB | Nephrol Dial Transplant Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor κB-induced inflammation.Authors - Ming Wu |
| WB | Chem Res Toxicol 4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.Authors - Mikhail Linetsky |
Complement C4 Protein and DNA Typing Methods
and factor B in the major histocompatibility complex (MHC) class III gene region between HLA-B and human leukocyte antigen (HLA)-DR (1 ). C4 polymorphism can be defined at three levels: (i) at the genomic level regarding the gene structure and the number
AP Assay and FGF Binding Mike Naski COS-7 cells were transfected by a standard DEAE-dextran method with 4 mg of plasmid/10 6 cells. Conditioned medium was harvested 3, 6 and 9 days after transfection and used for AP enzyme
Assaying NF-KB and AP-1 DNA-Binding and Transcriptional Activity
Nuclear factor-KB (NF-K B) and activator protein 1 (AP-1) are well-characterized ubiquitously expressed transcription factors that play important roles in the response to cellular stress situations. In unstimulated resting cells, NF-K B
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