重组人泛素结合酶E2-G2(UBCE2G2)

特别提示：包括重组人泛素结合酶E2-G2(UBCE2G2)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人泛素结合酶E2-G2(UBCE2G2)
英文名称：Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2
产品货号：JN0855
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Leu165在N端带有GST标签。

UBE2G2质量控制：＞95%(还原性SDS-PAGE)

UBE2G2制剂：液体

UBE2G2保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于UBE2G2：
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.

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