Anti-ACTN4 Polyclonal Antibody

产品简介

英文名称	Anti-ACTN4 Polyclonal Antibody
宿主	Rabbit
别名	ACTININ-4,FSGS,FSGS1,alpha-actinin-4
稀释比例	WB 1:8000-12000. IHC 1:100-300.
蛋白分子量	105/80/60kDa
Gene ID	81
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human ACTN4
性状	液体
亚细胞定位	Cytoplasm Nucleus
Swiss Prot	O43707
背景资料	Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Public Immunogen Range	75-125/911aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with ACTN4 antibody diluted at 1:10000;Lane:A375,NIH3T3

Immunohistochemistry?of?paraffin-embedded?Human pancreatic cancer?with?ACTN4 antibody diluted at 1:200