Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
实验图
Western blot analysis with VCL antibody diluted at 1:6000;Lane: HeLa,293T,NIH/3T3,PC-3M-IE8,HepG2,Mouse heart.
Immunohistochemistry of paraffin-embedded Human testis cancer with Vinculin antibody diluted at 1:200.