Anti-MCM4 Polyclonal Antibody

产品简介

单位	支
英文名称	Anti-MCM4 Polyclonal Antibody
别名	CDC21;CDC54;NKCD;NKGCD;P1-CDC21;hCdc21
宿主	Rabbit
稀释比例	WB 1:500-2000. IHC 1:50-200.
Gene ID	4173
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P33991
蛋白分子量	97kDa
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	A synthetic peptide of human MCM4
亚型	IgG
性状	液体
纯化方法	Affinity purification
背景资料	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Public Immunogen Range	A synthetic peptide of human MCM4
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Western blot analysis with MCM4 antibody diluted at 1:1000

Immunohistochemistry of paraffin-embedded B cell lymphoma(hu) using MCM4 antibody at dilution of 1:200 (x40 lens).