- ￥960 - 1600
- Solarbio
- 北京
- K108661P
- 2025年07月14日
- WB
- Rabbit
- Human ; Monkey ; Rat ; Mouse
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide of Human KEAP1
- 亚型：
IgG
- 形态：
液体/冻干粉
- 保存条件：
Store at -20°C. Avoid freeze / thaw cycles.
- 克隆性：
多克隆
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，SAlexa Fluor 350，SAlexa Fluor 405，SAlexa Fluor 488，SAlexa Fluor 532，SAlexa Fluor 555，SAlexa Fluor 568，SAlexa Fluor 594，SAlexa Fluor 633，SAlexa Fluor 640，SAlexa Fluor 647，SAlexa Fluor 660，SAlexa Fluor 680，SAlexa Fluor 750
- 适应物种：
Human ; Monkey ; Rat ; Mouse
- 保质期：
1-3年
- 抗原来源：
A synthetic peptide of Human KEAP1
- 目录编号：
9817
- 级别：
科研级别
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB
- 浓度：
WB 1:1000-3000.
- 靶点：
KEAP1
- 抗体英文名：
Anti-KEAP1 Polyclonal Antibody
- 抗体名：
kelch样蛋白ECH相关蛋白1抗体
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
Substrate-specific adapter of a BCR E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation. The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome.
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