- ￥960 - 1600
- Solarbio
- 北京
- K000072M
- 2025年07月10日
- IP ; IF ; ICC ; WB
- Mouse
- Human Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified recombinant human Pyruvate Dehydrogenase E2 protein fragments expressed in E.coli.
- 亚型：
IgG1
- 形态：
液体
- 保存条件：
Store at -20°C. Avoid freeze / thaw cycles.
- 克隆性：
单克隆
- 标记物：
详询
- 适应物种：
Human Mouse
- 保质期：
详询
- 抗原来源：
详询
- 目录编号：
K000072M
- 级别：
详询
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Mouse
- 应用范围：
IP ; IF ; ICC ; WB
- 浓度：
详询
- 靶点：
Pyruvate Dehydrogenase E2
- 抗体英文名：
Anti-Pyruvate Dehydrogenase E2 Monoclonal Antibody
- 抗体名：
DLTA;PDC-E2;PDCE2
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 宿主 | Mouse |
|---|---|
| 英文名称 | Anti-DLAT Monoclonal Antibody |
| 别名 | DLTA;PDC-E2;PDCE2 |
| 稀释比例 | WB 1:1000. ICC 1:300. |
| 蛋白分子量 | 69kDa |
| Gene ID | 1737 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | Purified recombinant human DLAT protein fragments expressed in E.coli. |
| 性状 | 液体 |
| 亚细胞定位 | Mitochondrion matrix |
| Swiss Prot | P10515 |
| 克隆号 | 4A4-B6-C10 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood |
| 应用 | WB ICC IP |
| 规格 | 50ul 100ul |
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