重组人前梯度同源蛋白2(AG-2)

特别提示：包括重组人前梯度同源蛋白2(AG-2)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人前梯度同源蛋白2(AG-2)
英文名称：Recombinant Human Anterior Gradient Protein 2 Homolog
产品货号：JN0556
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Arg21-Leu175在C端含有His标签。

AG-2质量控制：＞95%(还原性SDS-PAGE)

AG-2制剂：液体

AG-2保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于AG-2：
Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor. Mature human AGR2 is 155 amino acids (aa) in length (aa 21 - 175). Cys81 is presumed to participate in intermolecular bond formation. Over aa 21 - 175, human AGR2 shares 94% aa identity with mouse AGR2.

除了重组人前梯度同源蛋白2(AG-2),，我公司还供应以下相关产品：



名称：重组人白介素IL-12(白细胞介素12)
货号：JN0399
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Arg23-Ser219&Ile23-Ser328表达纯化而来。

IL-12质量控制：＞95%(还原性SDS-PAGE)。

IL-12制剂：冻干品

IL-12保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-12复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-12：
IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.Human and mouse IL‑12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.