重组小鼠Soggy-1(DkkL1)

特别提示：包括重组小鼠Soggy-1(DkkL1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠Soggy-1(DkkL1)
英文名称：Recombinant Mouse Dickkopf-like protein 1
产品货号：JN1456
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu21-Leu230在C端含有His标签。

Soggy-1/DkkL1 质量控制：＞95%(还原性SDS-PAGE)

Soggy-1/DkkL1 制剂：冻干品

Soggy-1/DkkL1 保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Soggy-1/DkkL1 复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Soggy-1/DkkL1 ：
The glycoprotein Dickkopf-like1, also known as soggy-1, is a member of Dickkopf (Dkk) family which modulates Wnt signaling by binding to the Wnt co-receptor lipoprotein receptor-related protein (Lrp) via two Cys-rich regions. Dkkl1 shows unique homology to a discrete region in Dkk3, however, it lacks the Lrp binding region that enables Wnt modulation. Dkkl1 expression is gradually upregulated during the development of mouse testis and corresponds to the mouse spermatogenesis. Mouse Dkkl1 is detected in the embryo, as well as in the developing skeleton, eyes and neural tissue. In adult animals the expressionof Dkkl1 is specific for spermatocytes and spermatids, where it regulates spermatocyte apoptosis mediated by Fas death ligand (FasL). Dkkl1 plays a critical role in male mammalian spermatogenesis.

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