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Mouse Anti Human Caspase and R

IP Adapter with Death Domain
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  • ¥1080 - 7500
  • Prospecbio
  • 以色列
  • ant-553
  • 2025年07月17日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      for future use below -18°C

    • 保质期

      See instructions

    • 英文名

      CRADD

    • 库存

      常规产品有备货

    • 供应商

      上海经科化学科技有限公司

    • CAS号

    • 规格

      5ug/20ug/100ug

    规格:5ug产品价格:¥1080.0
    规格:20ug产品价格:¥2415.0
    规格:100ug产品价格:¥7500.0

    产品细节图片1

    CATALOGUE NUMBER

    ANT-553

    SYNONYMS

    RAIDD, MGC9163, CRADD, Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CASP2 and RIPK1 domain containing adaptor with death domain.

    TYPE

    Mouse Anti Human Monoclonal.

    INTRODUCTION

    CRADD is a 22kDa, widely-expressed cytosolic adaptor/signaling protein that induces cell apoptosis/cell death in numerous tissues. CRADD is a death domain (CARD) that recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes TNFR1A, RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

    CLONE

    PAT14G8AT.

    PHYSICAL APPEARANCE

    Sterile filtered colorless solution.

    IMMUNOGEN

    Anti-human CRADD mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CRADD protein 1-199 amino acids purified from E. coli.

    IG SUBCLASS

    Mouse IgG1 heavy chain and k light chain.

    PURIFICATION METHOD

    CRADD antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.

    FORMULATION

    1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.

    STORAGE PROCEDURES

    For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. 
    Prevent freeze thaw cycles.

    STABILITY / SHELF LIFE

    12 months at -20°C. 1 month at 4°C.

    APPLICATIONS

    CRADD antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:500.

    SAFETY DATA SHEET

    SDS

    USAGE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    CRADD is a 22kDa, widely-expressed cytosolic adaptor/signaling protein that induces cell apoptosis/cell death in numerous tissues. CRADD is a death domain (CARD) that recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes TNFR1A, RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

    相关实验
    • 死亡受体的信号通路图

      相关专题 细胞凋亡专题 死亡受体(death receptor)包括多种分子 。有关死亡受体及其配体的研究是目前细胞凋亡 研究的热点之一。死亡受体均属TNFR 基因超家族,它们有相似的富含半胱氨酸的胞外结构域。死亡受体都含有同源的胞浆内序列,称为死亡结构域(death domain)或死亡区,其主要功能是介导死亡受体诱发的细胞凋亡 。目前所知的死亡受体主要有Fas、TNFR1、CAR1、NGFR、DR3

    • 死亡受体3,4,5诱导的细胞凋亡通路图

      known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades

    • Methods to Analyze Cellular Necroptosis

      execution is prevented, e.g. by caspase inhibitors. Although it occurs under regulated conditions, necroptotic cell death is characterized by the same morphological features as unregulated necrotic death. RIP1 kinase activity is a key step in the necroptosis

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    文献支持
    Mouse Anti Human Caspase and RIP Adapter with Death Domain
    ¥1080 - 7500