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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
for future use below -18°C
- 保质期:
See instructions
- 英文名:
CRADD
- 库存:
常规产品有备货
- 供应商:
上海经科化学科技有限公司
- CAS号:
无
- 规格:
5ug/20ug/100ug
| 规格: | 5ug | 产品价格: | ¥1080.0 |
|---|---|---|---|
| 规格: | 20ug | 产品价格: | ¥2415.0 |
| 规格: | 100ug | 产品价格: | ¥7500.0 |

CATALOGUE NUMBER
ANT-553
SYNONYMS
TYPE
INTRODUCTION
CLONE
PHYSICAL APPEARANCE
IMMUNOGEN
IG SUBCLASS
PURIFICATION METHOD
FORMULATION
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
STORAGE PROCEDURES
STABILITY / SHELF LIFE
APPLICATIONS
SAFETY DATA SHEET
SDS
USAGE
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文献和实验CRADD is a 22kDa, widely-expressed cytosolic adaptor/signaling protein that induces cell apoptosis/cell death in numerous tissues. CRADD is a death domain (CARD) that recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes TNFR1A, RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
相关专题 细胞凋亡专题 死亡受体(death receptor)包括多种分子 。有关死亡受体及其配体的研究是目前细胞凋亡 研究的热点之一。死亡受体均属TNFR 基因超家族,它们有相似的富含半胱氨酸的胞外结构域。死亡受体都含有同源的胞浆内序列,称为死亡结构域(death domain)或死亡区,其主要功能是介导死亡受体诱发的细胞凋亡 。目前所知的死亡受体主要有Fas、TNFR1、CAR1、NGFR、DR3
known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades
Methods to Analyze Cellular Necroptosis
execution is prevented, e.g. by caspase inhibitors. Although it occurs under regulated conditions, necroptotic cell death is characterized by the same morphological features as unregulated necrotic death. RIP1 kinase activity is a key step in the necroptosis
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