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Recombinant Human Heat Shock 2

2 kDa Protein-8

价格￥1080 - 21735

品牌Prospecbio
产地以色列
货号hsp-022
更新日期2025年07月11日

上海经科化学科技有限公司

16 年钻石会员

规格：	2ug	产品价格：	￥1080.0
规格：	10ug	产品价格：	￥2415.0
规格：	100ug	产品价格：	￥21735.0

CATALOGUE NUMBER

HSP-022

SYNONYMS

HSPB8, H11, HMN2, CMT2L, DHMN2, E2IG1, HMN2A, HSP22, Heat shock protein beta-8, Alpha-crystallin C chain, Small stress protein-like protein HSP22, E2-induced gene 1 protein, Protein kinase H11, CRYAC.

INTRODUCTION

HSPB8 displays temperature-dependent chaperone activity. HSPB8 acts as a mn(2+)-dependent serine-threonine- specific protein kinase. we are not convinced that this is its true role. Defects in HSPB8 are a cause of distal hereditary motor neuropathy type ii (DHMN2) also known as distal spinal muscular atrophy (DSMA) and spinal muscular atrophy of the charcot-marie-tooth type. it is an autosomal dominant disorder of lower motor neurons characterized by distal muscle weakness.

DESCRIPTION

Recombinant Human Heat Shock Protein 22 kDa Protein-8 is a full-length human HSP22 with an MW of 21604 Dalton produced in E.coli.

SOURCE

Escherichia Coli.

PHYSICAL APPEARANCE

Sterile Filtered White lyophilized (freeze-dried) powder.

FORMULATION

The HSPB8 protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Tris-acetate, pH-7.6, 10mM NaCl, 0.1mM EDTA, 0.1mM PMSF, 15mM b-ME.

SOLUBILITY

It is recommended to reconstitute the lyophilized HSPB8 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

STABILITY

Lyophilized HSPB8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution HSPB8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

PURITY

Greater than 95.0% as determined by SDS-PAGE.

IMMUNOLOGICAL ACTIVITY

Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSPB8.

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文献和实验

该产品被引用文献

Title: Roles of ERK and NF-?B in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells.
Publication: Korean J Physiol Pharmacol. 2008 Aug;12(4):171-176.

相关实验

Heat-Shock Protein Fusion Vectors for Improved Expression of Soluble Recombinant Proteins in Escherichia coli
Molecular chaperones or heat-shock proteins (HSPs) are protein machines that interact with unfolded or partially folded polypeptides and assist them in attaining their proper conformation. The folding reaction relies on a complex array
Enhancing Antigen Cross-Presentation and T-Cell Priming by Complexing Protein Antigen to Recombinant Large Heat-Shock Protein
Large heat-shock proteins (HSPs), including hsp110 and grp170, are unique immunochaperones capable of carrying and introducing antigens into professional antigen-presenting cells for efficient cross-presentation. Therefore, reconstituted
Stress Response Profiles in Human Fibroblasts Exposed to Heat Shock or Oxidative Stress
to evaluate the cellular capability to cope with exogenous stressors, we investigated stress response profiles in cultured human fibroblasts exposed to short-term heat shock or oxidative stress. Quantitative PCR analysis as well as Western blotting

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434 人阅读发布时间：2024-08-27 15:52

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Recombinant Human Heat Shock 22 kDa Protein-8

￥1080 - 21735

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Recombinant Human Heat Shock 2