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- pro-308
- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
RHEB
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
10ug/50ug/1mg
| 规格： | 10ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2415.0 |
| 规格： | 1mg | 产品价格： | ￥30429.0 |
CATALOGUE NUMBER
PRO-308
SYNONYMS
Ras homolog enriched in brain, RHEB2, Ras homolog enriched in brain, GTP-binding protein Rheb, RheB, Ras homolog enriched in brain GTP binding protein Rheb, Ras homolog enriched in brain 2, RHEB 2.
INTRODUCTION
RHEB is part of the Ras & GTPase superfamily that was originally identified as an immediate-early gene in brain but is also widely expressed in other tissues. RHEB encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. RHEB is necessary in regulation of growth and cell cycle progression due to its role in the TOR/S6K signaling pathway. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. RHEB induces oncogenic transformation. RHEB overexpression accelerates lymphomagenesis and is associated with prostate cancer. RHEB can cytopathologically distinguish between fibroadenoma from malignant breast carcinomas which is considered as a secondary diagnostic tool. RHEB has a central role in the regulation of the Ras/B-Raf/C-Raf/MEK signaling network.
DESCRIPTION
The RHEB is fused to T7-tag at N-terminus (16 a.a.) and is purified by standard chromatography techniques.
SOURCE
PHYSICAL APPEARANCE
FORMULATION
STABILITY
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
AMINO ACID SEQUENCE
SAFETY DATA SHEET
SDS
PURITY
USAGE
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文献和实验RHEB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 197 amino acids (1-181 amino acids) and having a molecular mass of 21.7 kDa.
The RHEB is fused to T7-tag at N-terminus (16 a.a.) and is purified by standard chromatography techniques.
Introduction of human 14-3-3 proteins
-3-3 protein and multiple signalling pathwaysChromosome assignment of human brain 14-3-3 protein eta chainSubcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies---------------------------------------------------------
Overexpression Models: Lentiviral Modeling of Brain Cancer
. Uhrbom, L., Hesselager, G., Nister, M., and Westermark, B. 1998. Induction of brain tumors in mice using a recombinant platelet‐derived growth factor B‐chain retrovirus. Cancer Res. 58:5275‐5279
症、糖尿病与心血管疾病。 小G蛋白Rheb(Ras homolog enriched in brain)是mTOR信号通路的关键调节蛋白，虽然调控Rheb的GTP水解酶激活蛋白(GAP)很早被发现，但是其鸟嘌呤交换因子(GEF)一直没有被鉴定出来。最近有实验表明果蝇 的TCTP(translationally controlled tumor protein) 对TOR信号传导通路有调控作用，有可能是Rheb的GEF。小鼠和拟兰芥中的遗传学实验表明TCTP对于细胞生长也有重要的调节
技术资料