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- 2025年07月15日
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- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
mNKp46
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
1ug/5ug/50ug
| 规格： | 1ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 5ug | 产品价格： | ￥2415.0 |
| 规格： | 50ug | 产品价格： | ￥17000.0 |
CATALOGUE NUMBER
PRO-2365
SYNONYMS
INTRODUCTION
| A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44, which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The Lysis of tumor cells by NK-cells involves recognition by NKp46 of heparan sulfate moieties of membrane heparan sulfate proteoglycans. Furthermore, NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46 (22-255aa) is purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. In addition, engagement of the antigen with the monoclonal antibody stimulates intracellular calcium levels and the synthesis of cytokines. CD59 is an NKp46 coreceptor (by physical association) together they activate cytotoxicity of human NK-cells, their engagement results in tyrosine phosphorylation of CD3-zeta chains associated with NKp46. Reduced cell surface expression of NKp46 and other NK-cell receptors is linked to the impaired NK-cell cytolytic function in viremic HIV-1 infection. |
DESCRIPTION
NKp46 is fused to a 239 amino acid hIgG-His Tag at C-terminus & purified by proprietary chromatographic techniques.
SOURCE
PHYSICAL APPEARANCE
FORMULATION
STABILITY
PURITY
AMINO ACID SEQUENCE
SAFETY DATA SHEET
SDS
USAGE
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文献和实验NKp46 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 481 amino acids (17-255 a.a) and having a molecular mass of 54.4kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).
NKp46 is fused to a 239 amino acid hIgG-His Tag at C-terminus & purified by proprietary chromatographic techniques.
Use of Activated Natural Killer Cells for Tumor Immunotherapy in Mouse and Human
Natural killer (NK) cells are a subset of lymphocytes with a distinct morphologic appearance (large granular lymphocytes [LGLs]) and the ability to spontaneously kill virally infected or tumor targets but to spare most normal cells
incubator. Longer incubation may occasionally be used, but natural killing should be completed within 4 hours and longer incubation may involve processes other than spontaneous killing (e.g. antibody-mediated cytotoxicity). After the incubation, add
Construction of RibonucleaseAntibody Conjugates for Selective Cytotoxicity
(1 ). Both recombinant RNase fusion proteins (2 –4 see also Chapter 6 , this volume) and chemical RNase conjugates have been made and characterized. The cytotoxic potential of targeted ribonuclease was first demonstrated with bovine RNase conjugated to transferrin
技术资料