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- 详细信息
- 技术资料
- 库存:
403
- 英文名:
Kaempferol
- CAS号:
520-18-3
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
-20℃
- 规格:
20mg|100mg
特别提示:包括*奈酚在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:*奈酚
英文名称:Kaempferol
产品货号:L10726
产品规格:20mg|100mg
属性
| CAS号 | 520-18-3 |
| 分子式 | C15H10O6 |
| 分子量 | 286.24 |
| 熔点 | 276℃ |
| 存贮条件 | 储存温度-20℃ |
| 密度 | 1.6880 |
描述
| 应用 | 一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-H-ras-转化的NIH 3T3细胞变形后的恢复。能显著诱导核DNA退化,同时伴随脂类的过氧化反应。抑制拓扑异构酶I催化的DNA再连接。 |
| 生化机理 | Description:IC50 value:Kaempferol inhibits proliferation of ovarian cancer cells at 40μM or higher concentrations[2].Kaempferol(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a relatively common nontoxic,natural dietary compound which has been reported to reduce the risk of ovarian cancer[1].in vitro:Kaempferol was found to inhibit estrogen receptor alpha expression in breast cancer cells and to induce apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.Studies have shown that kaempferol also has anti-inflammatory effects via inhibition of interleukin-4 and cyclo-oxygenase 2 expression by suppressing Src kinase and downregulating the NFκB pathway.Kaempferol is also effective in inhibiting angiogenesis and inducing apoptosis in ovarian cancer cells[1].kaempferol has a distinct epigenetic activity by inhibition of histone deacetylases(HDACs).In silico docking analysis revealed that it fits into the bindin |
| 别名 | 莰菲醇,3,4",5,7-四羟基黄酮,山柰素水合物;3,4",5,7-Tetrahydroxyflavone 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Robigenin |
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