Recombinant Human Butyrophilin

Butyrophilin Subfamily 3 Member A1, BTF5, DJ45P21.3 (Butyrophilin, Subfamily 3, Member A1), Butyrophilin, Subfamily 3, Member A1, CD277 Antigen, BTN3.1, BT3.1, CD277, Butyrophilin subfamily 3 member A1.

Butyrophilin sub family 3 member A1, also known as BTN3A1 is a member of the immunoglobulin superfamily. BTN3A1 is composed of an extracellular N-terminal IgV as well as a membrane proximal IgC domain followed by a transmembrane domain and also a cytoplasmic tail. BTN3A1 participates in T-cell activation and also in the adaptive immune response. Furthermore, BTN3A1 regulates the proliferation of activated T-cells & the release of cytokines and IFNG by activated T-cells. BTN3A1, Mediates the response of T-cells to infected as well as transformed cells which are categorized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

BTN3A1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 464 amino acids (30-254a.a.) and having a molecular mass of 51.1kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).
BTN3A1 is expressed with a 239 amino acid hIgG-His Tag at C-Terminus and purified by proprietary chromatographic techniques.

Sf9, Baculovirus cells.

Sterile Filtered colorless solution.

BTN3A1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by SDS-PAGE.

QFSVLGPSGP ILAMVGEDAD LPCHLFPTMS AETMELKWVS SSLRQVVNVY ADGKEVEDRQ SAPYRGRTSI LRDGITAGKA ALRIHNVTAS DSGKYLCYFQ DGDFYEKALV ELKVAALGSD LHVDVKGYKD GGIHLECRST GWYPQPQIQW SNNKGENIPT VEAPVVADGV GLYAVAASVI MRG.S/SGEGVS CTIRSSLLGL EKTASISIAD PFFRSAQRWI AALAGLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH.

SDS

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