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Recombinant Human Cyclin-Depen

dent Kinase Inhibitor 2C
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  • ¥1080 - 45885
  • Prospecbio
  • 以色列
  • pka-020
  • 2026年01月09日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      for future use below -18°C

    • 保质期

      See instructions

    • 英文名

      CDKN2C

    • 库存

      常规产品有备货

    • 供应商

      上海经科化学科技有限公司

    • CAS号

    • 规格

      5ug/20ug/1mg

    规格:5ug产品价格:¥1080.0
    规格:20ug产品价格:¥2415.0
    规格:1mg产品价格:¥45885.0

    产品细节图片1

    CATALOGUE NUMBER

    PKA-020

    SYNONYMS

    Cyclin-dependent kinase inhibitor 2C (p18 inhibits CDK4), cyclin-dependent kinase 4 inhibitor C, cyclin-dependent kinase 6 inhibitor p18, INK4C, p18, p18-INK6, p18-INK4C, CDK6 inhibitor p18, cyclin-dependent inhibitor, CDKN6, p18-INK4c.

    INTRODUCTION

    CDKN2C is a member of the CDKN2 cyclin-dependent kinase inhibitor family. CDKN2C cooperates with CDK4 or CDK6, and inhibits the activation of the CDK kinases, therefore acts as a cell growth regulator which regulates cell cycle G1 progression. CDKN2C suppresses the cell growth and proliferation with a correlated dependency on endogenous retinoblastoma protein RB. Studies in the knockout mice show CDKN2C takes part in regulating spermatogenesis, in addition to suppressing tumorigenesis.

    DESCRIPTION

    CDKN2C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-168 and having a molecular mass of 20.7kDa.
    CDKN2C is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    SOURCE

    E.coli.

    PHYSICAL APPEARANCE

    Sterile Filtered colorless solution.

    FORMULATION

    The CDKN2C solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl,
    2mM DTT and 10% glycerol.

    STABILITY

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
    Avoid multiple freeze-thaw cycles.

    PURITY

    Greater than 95% as determined by SDS-PAGE.

    AMINO ACID SEQUENCE

    MG./S-SHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ

    SAFETY DATA SHEET

    SDS

    USAGE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    CDKN2C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-168 and having a molecular mass of 20.7kDa.
    CDKN2C is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    相关实验
    • Kinase Inhibitor Profiling Using Chemoproteomics

      Quantitative chemoproteomics has recently emerged as an experimental approach to determine protein interaction profiles of small molecules in a given cell line or tissue. In contrast to standard biochemical and biophysical kinase assays

    • Detection of DNA-Dependent Protein Kinase in Extracts from Human and Rodent Cells

      The DNA-dependent protein kinase, DNA-PK, is required for DNA double-strand break repair and V(D)J recombination (1 –3 ). DNA-PK is composed of a large catalytic subunit of approx 460 kDa (DNA-PKcs) and a heterodimeric DNA targeting subunit

    • Measurement of Wee Kinase Activity

      or in purified preparations. Specific protocols include the production and purification of recombinant Cdc2/Cyclin B substrate, the production of crude subcellular extract fractions, the purification of endogenous or recombinant Wee kinases, Wee kinase assays

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    文献支持
    Recombinant Human Cyclin-Dependent Kinase Inhibitor 2C
    ¥1080 - 45885