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Recombinant Human FK506 Bindin

g Protein 5
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  • ￥1080 - 87906
  • Prospecbio
  • 以色列
  • enz-939
  • 2026年01月03日
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    上海经科化学科技有限公司
    16 年钻石会员

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    • 技术资料
    • 保存条件：

      for future use below -18°C

    • 保质期：

      See instructions

    • 英文名：

      FKBP5

    • 库存：

      常规产品有备货

    • 供应商：

      上海经科化学科技有限公司

    • CAS号：

      无

    • 规格：

      2ug/10ug/1mg

    规格：2ug产品价格：￥1080.0
    规格：10ug产品价格：￥2415.0
    规格：1mg产品价格：￥87906.0

     

    CATALOGUE NUMBER

    ENZ-939

    SYNONYMS

    FK506 Binding Protein 5, 54 KDa Progesterone Receptor-Associated Immunophilin, 51 KDa FK506-Binding Protein, Androgen-Regulated Protein 6, HSP90-Binding Immunophilin, FK506-Binding Protein 5, PPIase FKBP5, 51 KDa FKBP, FF1 Antigen, EC 5.2.1.8, Rotamase, FKBP-51, FKBP51, FKBP54, AIG6, P54, Peptidylprolyl Cis-Trans Isomerase, T-Cell FK506-Binding Protein, PPIASE, Ptg-10, FKBP-5, FKBP5.

    INTRODUCTION

    FK506 Binding Protein 5 (FKBP5) belongs to the immunophilin protein family, which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP5 is a cis-trans prolyl isomerase, which binds to the immunosuppressants FK506 and rapamycin. FKBP5 is an immunophilin protein with PPIase and co-chaperone activities. FKBP5 is assumed to mediate calcineurin inhibition. FKBP5 is a component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). In addition, FKBP5 interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein.

    DESCRIPTION

    FKBP5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Met1-Val457) containing 467 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 52.5kDa.

    SOURCE

    Escherichia Coli.

    PHYSICAL APPEARANCE

    Filtered White lyophilized (freeze-dried) powder.

    FORMULATION

    FKBP5 was filtered (0.4µm) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.

    SOLUBILITY

    It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Filter sterilize your culture media/working solutions containing this non-sterile FKBP5 before using in cell culture.

    STABILITY

    Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

    AMINO ACID SEQUENCE

    MKHHHHHHAS MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV.

    PURITY

    Greater than 90.0% as determined by SDS-PAGE.

    SAFETY DATA SHEET

    SDS

    USAGE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    FKBP5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Met1-Val457) containing 467 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 52.5kDa.

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    文献支持
    Recombinant Human FK506 Binding Protein 5
    ￥1080 - 87906