- ￥1080 - 30429
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- cyt-546
- 2025年12月28日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
TRAIL (114-281 a.a.)
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
10ug/50ug/1mg
| 规格： | 10ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2415.0 |
| 规格： | 1mg | 产品价格： | ￥30429.0 |
CATALOGUE NUMBER
CYT-546
SYNONYMS
INTRODUCTION
In humans, the gene that encodes for TRAIL is located at chromosome 3q26.
TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.
DESCRIPTION
SOURCE
PHYSICAL APPEARANCE
FORMULATION
1mg/ml in 20mM Tris-HCl pH-7.5, 300mM NaCl, 0.1mM DTT & 10% glycerol.
STABILITY
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
PURITY
AMINO ACID SEQUENCE
SAFETY DATA SHEET
SDS
USAGE
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文献和实验Soluble TNF-related apoptosis-inducing ligand Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (114-281) and having a molecular mass of 19.6 kDa. The sTRAIL is purified by proprietary chromatographic techniques.
(9 ). Because its systemic administration was shown to mediate the regression of some mouse tumors (10 ), TNF-α has attracted much attention as a potential antitumor reagent (11 ). However, the problem of its dose-dependent toxicity has been particularly apparent in human
Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy
, TNF-related apoptosis-inducing ligand (TRAIL), or Apo-2 ligand, has generated excitement because of its unique ability to induce apoptosis in a wide range of transformed cell lines but not in normal tissues. TRAIL is well tolerated when given
细胞分泌的FasL可以杀伤免疫细胞，使其不能与害自己。这一假说受到如下实验的支持：在体外实验系统，FasL高表达的肿瘤细胞能杀乏Fas阳性的免疫细胞如T细胞。此外，在表达FasL的肿瘤组织可以检测到凋亡的肿瘤启过性淋巴细胞。然而，并非所有的实验结果都与此结果一致。 死亡受体介导的凋亡 (三)TRAIL／Apo2L TNF-α相关凋亡诱导配体(TNF related apoptosis inducing ligand，TRAIL)是从人类基因组数据库中寻找的与TNF(19％同源)和Fas L
技术资料