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Recombinant Human Growth and D

ifferentiation factor 15, His Tag
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  • ¥1080 - 87906
  • Prospecbio
  • 以色列
  • cyt-691
  • 2025年12月24日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      for future use below -18°C

    • 保质期

      See instructions

    • 英文名

      GDF15, His

    • 库存

      部分小规格有备货

    • 供应商

      上海经科化学科技有限公司

    • CAS号

    • 规格

      2ug/10ug/1mg

    规格:2ug产品价格:¥1080.0
    规格:10ug产品价格:¥2415.0
    规格:1mg产品价格:¥87906.0

    产品细节图片1

    CATALOGUE NUMBER

    CYT-691

    SYNONYMS

    GDF-15, MIC1, MIC-1, NAG-1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, Prostate differentiation factor, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, NRG-1, GDF15.

    INTRODUCTION

    GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.

    DESCRIPTION

    Recombinant Human GDF15 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids (195-308) and having a molecular mass of 16.7 kDa(molecular weight on SDS-PAGE will appear higher).
    GDF15 is expressed with a 36 amino acid His tag fused at N-Terminus and purified by proprietary chromatographic techniques.

    SOURCE

    Escherichia Coli.

    PHYSICAL APPEARANCE

    Sterile filtered colorless solution.

    FORMULATION

    The GDF15 protein solution contains 10mM sodium citrate, pH-3.5 & 10% glycerol.

    STABILITY

    Store at 4°C if entire vial will be used within 2-4 weeks.
    Store, frozen at -20°C for longer periods of time.
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
    Avoid multiple freeze-thaw cycles.

    PURITY

    Greater than 95.0% as determined by SDS-PAGE.

    AMINO ACID SEQUENCE

    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I.

    SAFETY DATA SHEET

    SDS

    USAGE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    Recombinant Human GDF15 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids (195-308) and having a molecular mass of 16.7 kDa(molecular weight on SDS-PAGE will appear higher).
    GDF15 is expressed with a 36 amino acid His tag fused at N-Terminus and purified by proprietary chromatographic techniques.

    相关实验
    • Purification of Human Multiprotein Complexes using OneSTrEP Technology

      . For more theoretical background and a protocol for purification of recombinant Strep -tag® fusion proteins from E.coli please refer to Schmidt and Skerra (2007). In comparison to other commonly used purification strategies (i.e. HA and FLAG double-tag

    • 1 月内连登 4 顶刊,这个炙手可热的明星蛋白 GDF15 到底什么来路?

      作用。图片来源:Cell Metabolism这是 GDF15 继 2019 年 12 月先后登上 Nature Metabolism 和 Nature 之后,再次出现在顶级期刊上。下面就随着小编来看看 GDF15 这个热门蛋白的来路以及相关的 4 篇论文吧。GDF15 有啥来路?生长分化因子-15Growth/differentiation factor 15,GDF15)是转化生长因子-β 超家族(TGFβ super family)的一员。此前 GDF15 被发现在创伤过后的多种器官出现明显

    • PriCells: Introduction of Isolation and Culture of Human Alveolar Epithelial Cells

      control of proliferation of peripheral lung cells, metabolism and/or degradation of peptides and peptide growth factors, generation of cyto/chemokines, regulation of alveolar fluid balance, and transcellular ion and water transport. 1.3. Differentiation

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    文献支持
    Recombinant Human Growth and Differentiation factor 15, His Tag
    ¥1080 - 87906