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Recombinant Human Activin-A Ac

tive
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  • ¥1080 - 23000
  • Prospecbio
  • 以色列
  • cyt-414
  • 2025年07月18日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      for future use below -18°C

    • 保质期

      See instructions

    • 英文名

      Activin A, Plant-Active

    • 库存

      部分小规格有备货

    • 供应商

      上海经科化学科技有限公司

    • 规格

      1ug/5ug/100ug

    规格:1ug产品价格:¥1080.0
    规格:5ug产品价格:¥2415.0
    规格:100ug产品价格:¥23000.0

    产品细节图片1

    CATALOGUE NUMBER

    CYT-414

    SYNONYMS

    Inhba, Inhibin beta A, FSH releasing protein.

    INTRODUCTION

    Activins are homodimers or heterodimers of the different β subunit isoforms, part of the TGFβ family. Mature Activin A has two 116 amino acids residues βA subunits (βA-βA). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.

    DESCRIPTION

    Active form Activin-A Human Recombinant produced in Plant is a homodimeric, glycosylated, polypeptide chain containing 2 x 116 amino acids and having a molecular weight of 27.4kDa.
    The Active form Activin-A is fused to a 6-His tag at N-terminus and purified by standard chromatographic techniques.

    SOURCE

    Nicotiana benthamiana.

    PHYSICAL APPEARANCE

    Lyophilized freeze dried powder.

    FORMULATION

    Active form Activin-A was lyophilized from a concentrated 1mg/ml protein solution containing 50mM Tris-HCl pH-7.4

    STABILITY

    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended.

    SOLUBILITY

    INHBA protein should be reconstituted in distilled water to a concentration of 50 ug /ml. Due to the protein nature, dimmers and multimers may be observed.

    AMINO ACID SEQUENCE

    HHHHHHGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSG
    YHANYCEGECPSHIAGTSg-s-sLSFHSTVINHYRMRGHSPFA
    NLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS.

    BIOLOGICAL ACTIVITY

    The biological activity of INHBA is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation ([3H]thymidine incorporation). ED50<5ng/ml.

    PURITY

    Greater than 98% as obsereved by SDS-PAGE.

    SAFETY DATA SHEET

    SDS

    USAGE

    ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    Activins are homodimers or heterodimers of the different β subunit isoforms, part of the TGFβ family. Mature Activin A has two 116 amino acids residues βA subunits (βA-βA). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.

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    ¥1080 - 23000