AG-1478(Tyrphostin AG-1478)(≥9

特别提示：包括AG-1478(Tyrphostin AG-1478)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：AG-1478(Tyrphostin AG-1478)
英文名称：AG-1478(Tyrphostin AG-1478)
产品货号：L10107
产品规格：5mg|10mg|25mg|50mg
 

属性

CAS号	153436-53-4
分子式	C16H14ClN3O2
分子量	315.75
溶解性	25℃:DMSO 25mg/mL;Water<1 mg/mL;Ethanol 13 mg/mL
存贮条件	储存温度-20℃
密度	1.3370

描述

产品介绍	AG-1478(NSC 693255)是高效EGFR选择性抑制剂，IC50为3 nM，对HER2-Neu，PDGFR，Trk，Bcr-Abl和InsR无活性。
备注	AG-1478(Tyrphostin AG-1478) is a selectiveEGFRinhibitor withIC50of 3 nM,almost no activity on HER2-Neu,PDGFR,Trk,Bcr-Abl and InsR.
生化机理	AG1478 inhibited EGFR phosphorylation in CNE2 cells without reduced expression of EGFR protein.The activation of Akt and MAPK which are downstream molecules of EGFR signaling pathway,were also inhibited by AG1478.Although AG 1478 inhibited cell growth,DNA synthesis,EGFR tyrosine kinase activity,and receptor autophosphorylation of each cell line in a dose-dependent manner,it was significantly more potent in U87MG.delta EGFR cells than in the other two cell lines. in vivo:At the lowest dose,plasma drug levels after the cessation of infusion declined with a half-life of approximately 43min.EGFR activity,measured both by autophosphorylation and downstream signalling,was inhibited in a dose-dependent manner by injection of AG1478 in mice bearing xenografts of the human glioblastoma cell line U87MG
别名	酪氨酸激酶抑制剂AG 1478;N-(3-氯*基)-6,7-二甲氧基-4-氨基喹唑啉;(3-氯*基)(6,7-二甲氧基喹唑啉-4-基)胺;Tyrphostin AG-1478;AG 1478;NSC 693255;AG1478;N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine;3-chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine