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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
Mouse IgG1, κ
- 形态:
液体
- 保存条件:
This product can be stored at 2-8°C for 12 months. Do not freeze.
- 克隆性:
Monoclonal
- 标记物:
None (Purified antibody-Azide Free/Low endotoxin)
- 适应物种:
Human
- 保质期:
12个月
- 目录编号:
E-AB-F12130
- 级别:
科研
- 库存:
999
- 供应商:
武汉伊莱瑞特生物科技股份有限公司
- 宿主:
Mouse
- 应用范围:
FCM
- 抗体英文名:
AF/LE Purified Anti-Human CD279/PD-1 Antibody[J110]_货号:E-AB-F12130
- 抗体名:
AF/LE Purified Anti-Human CD279/PD-1 Antibody流式抗体[J110]_货号:E-AB-F12130
- 规格:
500μg/50μg/1mg
| 规格: | 500μg | 产品价格: | ¥3160.0 |
|---|---|---|---|
| 规格: | 50μg | 产品价格: | ¥760.0 |
| 规格: | 1mg | 产品价格: | ¥4760.0 |

AF/LE Purified Anti-Human CD279/PD-1 抗体流式抗体[J110]产品名称:AF/LE Purified Anti-Human CD279/PD-1 Antibody[J110], 货号:E-AB-F12130
| 产品描述: | Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| Alternate Names | PDCD1;PD1;Protein PD-1;hPD-1; |
| Swissprot | Q15116 |
| Gene ID | 5133 |
| Clone No | J110 |
| Host | Mouse |
| Reactivity | Human |
| Application | FCM |
| 同种型 | Mouse IgG1, κ |
| 同种型 Control | AF/LE Purified Mouse IgG1, κ 同种型 Control[MOPC-21] |
| Conjugation | None (Purified antibody-Azide Free/Low endotoxin) |
| 储存方法 缓冲 | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
| 储存方法 | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Expiration date | 12个月 |
| Shipping | 冰袋 |

AF/LE Purified Anti-Human CD279/PD-1 抗体流式抗体[J110]labscience®拥有先进的单抗,多抗和流式抗体开发技术平台,提供8500+高品质 抗体, 适用于胞内和胞外蛋白的鉴定、定量和定位研究。抗体已在多种应用中得到验证,包含 流式细胞术(Flow Cytometry)、 免疫印迹(WB)、 免疫组化(IHC/ICC)、 免疫(共)沉淀(IP/Co-IP)、 免疫荧光(IF) 等实验。抗体产品涉及多种生命科学研究领域,包括肿瘤、免疫、心血管、细胞生物学、神经科学、表观遗传学等。Elabscience®始终致力于提高抗体的质量和种类,以保障并加快您的研究进程
This product can be stored at 2-8°C for 12 months. Do not freeze.AF/LE Purified Anti-Human CD279/PD-1 抗体流式抗体[J110]产品更多产品信息查看欢迎咨询我们和搜索武汉伊莱瑞特Elabscience官网查看。
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文献和实验STM:傅阳心、侯玉柱等发现放疗与免疫治疗的交汇点,兵家必争之地竟是这群细胞
究竟是哪些 T 细胞亚群发挥了上述作用,研究人员使用抗体清除 CD4 + 或 CD8+ T 细胞。结果发现,只有 CD8+ T 细胞的减少能够消除了放疗诱导的 Ter 细胞减少,这表明是 CD8 + 而不是 CD4+ T 细胞发挥作用。 图片来源:Sci. Transl. Med PD-L1 阻断治疗减少肿瘤诱导的 Ter 细胞积累 免疫疗法,包括 PD-L1 和 PD-1 阻断等,是有望治疗许多癌症的方法。PD-L1 阻断能够增强 CD8+ T 细胞的免疫功能,包括干扰素的产生和细胞毒活性的增强
., Wang, T., Huang, Y., Wei, L., Li, J., Wang, Z., Hu, H., Yang, P., Le, L., Stenson, P.D., Li, B., Liu, X., Ball, E.V., An, N., Huang, Q., Zhang, Y., Fan, W., Zhang, X., Li, Y., Wang, W., Katze, M.G., Su, B., Nielsen, R., Yang, H., Wang, J., Wang, X
15 August 2011. ^ a b Wheeler, B.; Heimberg, A.; Moy, V.; Sperling, E.; Holstein, T.; Heber, S.; Peterson, K. (2009). "The deep evolution of metazoan microRNAs". Evolution & development 11 (1): 50–68. doi:10.1111/j.1525-142X.2008.00302.x. PMID
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