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- 文献和实验
- 技术资料
- 抗体名:
APC Anti-Human CD273/PD-L2 Antibody流式抗体[24F.10C12]_货号:E-AB-F1175E
- 抗体英文名:
APC Anti-Human CD273/PD-L2 Antibody[24F.10C12]_货号:E-AB-F1175E
- 应用范围:
FCM
- 宿主:
Mouse
- 适应物种:
Human
- 保质期:
12个月
- 目录编号:
E-AB-F1175E
- 级别:
科研
- 库存:
999
- 供应商:
武汉伊莱瑞特生物科技股份有限公司
- 标记物:
APC
- 克隆性:
Monoclonal
- 保存条件:
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
- 形态:
液体
- 亚型:
Mouse IgG2a, κ
- 规格:
100Tests/20Tests/100Tests×2
| 规格: | 100Tests | 产品价格: | ¥3120.0 |
|---|---|---|---|
| 规格: | 20Tests | 产品价格: | ¥1200.0 |
| 规格: | 100Tests×2 | 产品价格: | ¥4680.0 |
货号:E-AB-F1175E
| Background |
CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.
|
| Alternate Names |
B7DC; CD273; PDCD1L2; PDL2;
|
| Swissprot |
Q9BQ51
|
| Gene ID |
80380
|
| Clone No |
24F.10C12
|
| Host |
Mouse
|
| Reactivity |
Human
|
| Application |
FCM
|
| Isotype |
Mouse IgG2a, κ
|
| Isotype Control |
APC Mouse IgG2a, κ Isotype Control[C1.18.4]
|
| Conjugation |
APC
|
| Conjugation Information |
APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
|
| Storage Buffer |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
|
| Storage |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
|
| Expiration date |
12个月
|
| Shipping |
冰袋
|
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灌洗液(BALF)免疫细胞群体的剧烈重塑。在LPS刺激24小时后,肺部微环境发生了从“稳态维持”向“急性炎症爆发”的根本性转变。中性粒细胞取代了原本的常驻细胞,成为BALF中的绝对优势群体,而肺泡巨噬细胞的比例则出现了断崖式下跌。 Elabscience®相关产品推荐 货号 产品名称 AN00871E APC 标记抗小鼠MERTK抗体[2B10C42] E-AB-F09832E APC 标记大鼠IgG2a,κ同型对照抗体[2A3] E-AB-F0990Q2 Elab Bright™
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究竟是哪些 T 细胞亚群发挥了上述作用,研究人员使用抗体清除 CD4 + 或 CD8+ T 细胞。结果发现,只有 CD8+ T 细胞的减少能够消除了放疗诱导的 Ter 细胞减少,这表明是 CD8 + 而不是 CD4+ T 细胞发挥作用。 图片来源:Sci. Transl. Med PD-L1 阻断治疗减少肿瘤诱导的 Ter 细胞积累 免疫疗法,包括 PD-L1 和 PD-1 阻断等,是有望治疗许多癌症的方法。PD-L1 阻断能够增强 CD8+ T 细胞的免疫功能,包括干扰素的产生和细胞毒活性的增强
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