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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Human
- 目录编号:
GTX83029
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Mouse
- 应用范围:
WB, ELISA
- 靶点:
Syk
- 抗体英文名:
Syk antibody [8C1A3]
- 抗体名:
Syk 抗体 [8C1A3]
- 规格:
100 μl
WB analysis of truncated SYK-His recombinant protein (1) and PMA induced THP-1 cell lysate (2) using GTX83029 Syk antibody [8C1A3].
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文献和实验到 Aβ 沉积处,试图吞噬并清除这些“垃圾”。它们通过 TREM2、LRP1、P2X7、TLR2/4/6、CD36 等受体识别 AβO。其中,TREM2 的作用尤为关键——当 AβO 与其结合后,通过衔接蛋白 DAP12 激活 SYK 通路,促进 Aβ 降解。研究发现,TREM2 缺失会显著加重早期 Aβ 病理[3][4]。 但问题在于:这种警报如果长期拉响,守卫也会被拖垮。 这些长期暴露于 Aβ 的小胶质细胞逐渐向 DAM (Disease-associated microglia,疾病相关小胶
General Principles of Immunoprecipitation
---------------------------------------------------------------------------- Beware of fragile kinases.The kinase activities of Syk and the p60src proteins of tsRSVs,are labile.Most of their activity is lost in RIPA.For these proteins,it is important to use NP-40 buffer,containing EDTA
Intracellular Cytokine Staining Protocol
anti-cytokine antibodies with excess amounts of unlabeled antibody. Alternatively, recombinant cytokines can be used for blocking.eBioscience antibodies are available as Functional Grade (FG) Purified (sterile, endotoxin-tested, no azide), Purified
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