ERCC1 mouse monoclonal antibod

gene_symbol：ERCC1
predicted_size：32.4 kDa
Uniprot ID：P7992
description：ERCC1 mouse monoclonal antibody, clone OTI5A2 (formerly 5A2)
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq]
immunogen：Full length human recombinant protein of human ERCC1(NP_001974) produced in HEK293T cell.
recommended_dilution：WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100
predicted_size：32.4 kDa
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
host_species：Mouse
applications：FC, IF, IHC, WB
reactivities：Human, Mouse