OriGene NELFE Rabbit Monoclona

ProductName：NELFE Rabbit Monoclonal Antibody [Clone ID: R02-7E5]
description：NELFE Rabbit monoclonal Antibody
symbol：NELFE
synonyms：D6S45; NELF-E; RD; RDBP; RDP
locusid：7936
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P18615
Applications：IHC, IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
IHC: 1/20
IP: 1/20
Reactivity：Human, Mouse, Rat
Immunogen：Recombinant protein of human NELFe
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：negative elongation factor complex member E
Background：Swiss-Prot Acc.P18615.Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 43 kDa; Observed MW: 43 kDa