PI 3 Kinase p85 alpha (PIK3R1)

gene_symbol：PIK3R1
predicted_size：~ 85 kDa
Uniprot ID：P27986
description：PI 3 Kinase p85 alpha (PIK3R1) rabbit polyclonal antibody, Aff - Purified
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulinstimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
immunogen：Synthetic peptide, corresponding to amino acids 470-510 of Human PI3K p85α.
recommended_dilution：Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
predicted_size：~ 85 kDa
buffer：Phosphate buffered saline (PBS), pH 7.2.; State: Aff - Purified; State: Liquid purified Ig fraction; Preservative: 15 mM sodium azide
host_species：Rabbit
applications：IHC, WB
reactivities：Human, Mouse, Rat