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- sigma
- D7443-5MG
- 美国
- 2026年03月23日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
嵘崴达
- 库存：
该产品已停产
- 保存条件：
2-8°C
- CAS号：
43077-30-1
- 英文名：
DPO-1
- 保质期：
见产品外包装
- 规格：
5 mg
DPO-1
needles, >97% (NMR)
别名: (+)-Neomenthyl diphenylphosphine oxide, (1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide
包装
5, 25 mg in glass bottle
Biochem/physiol Actions
DPO-1 is an inhibitor of human Kv1.5 potassium channel; representative blocker of a novel pharmacophore. The Kv1.5 potassium channel, which underlies the ultrarapid delayed rectifier current, IKur, is reported to be enriched in human atrium versus ventricle, and has been proposed as a target for novel atrial antiarrhythmic therapy. The administration of the IKur blocker (2-isopropyl-5-methyl-cyclohexyl) diphenylphosphine oxide (DPO-1) increases myocardial refractoriness in both atrium and ventricle of rat, but produces an atrial-selective increase in refractoriness in primates; appears to be 15-fold more selective for Kv1.5 vs Kv3.1 channels expressed in Xenopus oocytes. IC50 = 0.16-0.76 μM at 0.1 Hz pulsing frequency; Kd = 0.6 μM.
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds.
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文献和实验慢性胃炎 有肯定的疗效，而且副作用小、宜于接受。本文就丽球得乐冲剂在我院临庆上的应用情况作一简介，供广大同行参考。 1 对象和方法 本组资料选自1990－05～1990－10本院门诊、病房共50例 胃溃疡 患者。治疗方法是：CBS冲剂每次1袋（每袋含胶态枸橼酸铋0.3g），4次/dpo，连服60d。 2 结果 治疗效果与文献报道胶态铋剂对胃炎和 胃溃疡 相关
Liquid Chromatography‐Mass Spectrometry Analysis of DNA Polymerase Reaction Products
., and Guengerich, F.P. 2005. DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4. Analysis and crystal structures of multiple base‐pair substitution and frameshift product with the adduct 1,N2‐ethenoguanine. J. Biol. Chem. 280:29750
Eoff, R.L., Irimia, A., Egli, M., and Guengerich, F.P. 2007. Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by “Wobble” pairing between O6‐methylguanine and cytosine, but accurate bypass is preferred. J. Biol. Chem
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