重组人凝血因子VIIa

产品英文名称：
Recombinant Human Factor VIIa

英文简称:
Factor-VIIa

中文名称:
重组人凝血因子VIIa

背景资料:
Coagulation factor VII is a vitamin K-dependent factor which is essential for hemostasis. It circulates in the blood as a zymogen which is later converted to an active form by factor IXa， factor Xa， factor XIIa， or thrombin by minor proteolysis. Upon activation of factor VII， a heavy chain with a catalytic domain and a light chain with 2 EGF-like domains are generated， and the two chains are held together by a disulfide bond. The presence of factor III and calcium ions further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of factor VII results in 2 transcripts. Defects in coagulation factor VII can cause coagulopathy. Coagulation factor VII initiates the extrinsic pathway of blood coagulation. Minor proteolysis converts factor VII to factor VIIa by factors Xa， XIIa， IXa， or thrombin. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium.

产品描述:
Factor VIIa Human Recombinant produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD. The Factor-VIIa is purified by proprietary chromatographic techniques.
来源宿主:
幼年仓鼠肾细胞BHK细胞中重组表达

序列:


溶解建议:
Sterile Filtered White lyophilized （freeze-dried） powder. The protein 1 mg/ml was lyophilized after from a sterile solution containing 4.86 mg sodium chloride， 2.45 mg calcium chloride dihydrate， 50 mg mannitol and 116 ug Tween 80. It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.

保存建议：
Lyophilized Factor-VIIa although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Factor-VIIa should be stored at 4℃ between 2-7 days and for future use below -18℃. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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