产品英文名称: Recombinant Human Protein Arginine Methyltransferase 1
英文简称: PRMT1
中文名称: 重组人蛋白质精氨酸甲基转移酶-1
背景资料: PRMT1 Methylates(mono & asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain(may methylate HNRNPA1 and histones). Methylates SUPT5H.The PRMT1 protein functions as a histone methyltransferase specific for H4.PRMT1 is an essential factor in oncogenesis and is a potential novel therapeutic target in cancer.PRMT1-mediated methylation serves as a positive modulator of IR/IRS-1/PI3K pathway and glucose uptake in skeletal muscle cells.CAF1 is a new regulator of PRMT1-dependent arginine methylation.PRMT1 arginine-methylates MRE11 therefore it regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.PRMT1 plays a post-translationally part in regulating the transcriptional activity.PRMT1 is found predominantly in the cytoplasma though a fraction of PRMT1 is located in the nucleus.