产品英文名称: Recombinant Human Tumor Necrosis Factor Receptor Type 2
英文简称: TNFR2
中文名称: 重组人2型肿瘤坏死因子受体
背景资料: TNFR2 belongs to the TNF-receptor superfamily. TNFR2 is receptor with high a大肠杆菌中重组表达inity for TNFSF2/TNF-alpha and approximately 5-fold lower a大肠杆菌中重组表达inity for homotrimeric TNFSF1/lymphotoxin-alpha. TNFR2 mediates the majority of the metabolic e大肠杆菌中重组表达ects of TNF-alpha. In addition,knockout studies in mice propose a role for TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2 expression might have a significant role in the angiogenesis,tumor cell proliferation and metastasis of Invasive micropapillary carcinoma of the breast.There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II,which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors s人2型肿瘤坏死因子受体重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有184个氨基酸片段(23-206),在其氨基末端融合了一个分子量为4.5kDa的6xHis标签,分子量为24.45kDa.该人2型肿瘤坏死因子受体重组蛋白最终由标准的色谱技术纯化出.m to increase as a result of shedding of the extracellular domains of the membrane bound receptors. High levels of soluble TNF receptors are found in the amniotic fluid of pregnant women. TNFR2 and TNFR1 form a heterocomplex which mediates the recruitment of 2 anti-apoptotic proteins,c-IAP1 and c-IAP2,which possess E3 ubiquitin ligase activity. IAPs’ function in TNF-receptor signaling is unknown; nevertheless,c-IAP1 is believed to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2,which mediates anti-apoptotic signals. Oxidative stress promotes TNFR1 and TNFR2 self-interaction,ligand-independent and enhanced ligand-dependent TNF signaling. TNF-a,TNFR1 and TNFR2 have roles in cellular di大肠杆菌中重组表达erentiation. TNFR1 and TNFR2 function in cell type-specific renal injury.