重组小鼠TIE-2 Fc嵌合体

产品英文名称：
Recombinant Mouse TIE-2 Fc Chimera

英文简称:
mTIE-2 Fc

中文名称:
重组小鼠TIE-2 Fc嵌合体

背景资料:
TIE-1 （tyrosine kinase with Ig and EGF homology domains 1） and TIE-2/Tek comprise a receptor tyrosine kinase （RTK） subfamily with unique structural characteristics: two immunoglobulin-like domains flanking thrSoluble TIE-2 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a monomeric， glycosylated， polypeptide containing 740 amino acids and having a total molecular mass of 260 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation， the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions. The TIE2 Fc Chimera is purified by proprietary chromatographic techniques. epidermal growth factor （EGF）-like domains and followed by thrSoluble TIE-2 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a monomeric， glycosylated， polypeptide containing 740 amino acids and having a total molecular mass of 260 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation， the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions. The TIE2 Fc Chimera is purified by proprietary chromatographic techniques. fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis， vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1122 amino acid （aa） residue precursor protein with an 18 residue putative signal peptide， a 726 residue extracellular domain and a 353 residue cytoplasmic domain. Two ligands， angiopoietin-1 （Ang1） and angiopoietin-2 （Ang2）， which bind TIE-2 with high-aCHO中国仓鼠卵巢细胞中重组表达inity have bSoluble TIE-2 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a monomeric， glycosylated， polypeptide containing 740 amino acids and having a total molecular mass of 260 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation， the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions. The TIE2 Fc Chimera is purified by proprietary chromatographic techniques.n identified. Ang2 has bSoluble TIE-2 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a monomeric， glycosylated， polypeptide containing 740 amino acids and having a total molecular mass of 260 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation， the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions. The TIE2 Fc Chimera is purified by proprietary chromatographic techniques.n reported to act as an antagonist for Ang1. Mice enginSoluble TIE-2 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a monomeric， glycosylated， polypeptide containing 740 amino acids and having a total molecular mass of 260 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation， the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions. The TIE2 Fc Chimera is purified by proprietary chromatographic techniques.red to overexpress Ang2 or to lack Ang1 or Tie-1 display similar angiogenic defects.

产品描述:
Soluble TIE-2 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO is a monomeric， glycosylated， polypeptide containing 740 amino acids and having a total molecular mass of 260 kDa. Mouse TIE-2/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation， the recombinant protein migrates as an approximately 140 kDa protein in SDS-PAGE under reducing conditions. The TIE2 Fc Chimera is purified by proprietary chromatographic techniques.
来源宿主:
CHO中国仓鼠卵巢细胞中重组表达

序列:


溶解建议:
提供的小鼠TIE-2 Fc嵌合体（mTIE-2 Fc）产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1mg/ml小鼠TIE-2 Fc嵌合体（mTIE-2 Fc）的1x PBS溶液中过滤灭菌并冻干产生的.我们建议加无菌水以配制工作储存液到不低于100ug/ml，后继实验过程中可根据实验要求进一步稀释.

保存建议：
小鼠TIE-2 Fc嵌合体（mTIE-2 Fc）冻干粉末在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天以上；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存.请避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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