重组人颗粒钙蛋白

产品英文名称：
Recombinant Human Glycoprotein-2

英文简称:
GP2

中文名称:
重组人糖蛋白2

背景资料:
Crohn’s Disease （CD）， which is very common in Caucasians， is an inflammatory bowel diseases （IBD）. Mucosal inflammation in CD sGP2 is a cDNA coding for the free form of the human pancreatic secretory granule membrane major glycoprotein / GP2 having a molecular mass of 54，909 Dalton （protein component excluding glycosylation； observed molecular weight approx. 68 kDa） pH 5.4. GP2 protein is fused to a deca-histidine purification tag.ms to arise when dysregulation of the immune system breaks the balance betwGP2 is a cDNA coding for the free form of the human pancreatic secretory granule membrane major glycoprotein / GP2 having a molecular mass of 54，909 Dalton （protein component excluding glycosylation； observed molecular weight approx. 68 kDa） pH 5.4. GP2 protein is fused to a deca-histidine purification tag.n tolerance to commensal microbiota or food-derived antigens and immunity to pathogens. The autoimmune mechanisms takes part in the development of CD， and exocrine pancreas autoantibodies （PAB） are disease-specific in CD patients. It was established not too long ago that glycoprotein 2 （GP2） is the major autoantigenic mark recognized by CD-specific PAB. Furthermore to IgG and IgM PAB isotypes， IgA pancreatic autoantibodies were also identified in CD patients. GP2 is an extremely glycosylated 78 kDa protein with N-linked carbohydrates. It is responsible for up to 40% of all zymogen granule （ZG） membrane proteins in pancreatic acinar cells and is linked to the ZG membrane via a glycosyl phosphoinositol （GPI） anchor.

产品描述:
GP2 is a cDNA coding for the free form of the human pancreatic secretory granule membrane major glycoprotein / GP2 having a molecular mass of 54，909 Dalton （protein component excluding glycosylation； observed molecular weight approx. 68 kDa） pH 5.4. GP2 protein is fused to a deca-histidine purification tag.
来源宿主:
Sf9 昆虫细胞重组表达

序列:


溶解建议:
提供的重组人糖蛋白2产品形式为经无菌过滤处理的无色溶液.

保存建议：
重组人糖蛋白2产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。