重组人黑素瘤抗原家族A， 4

产品英文名称：
Recombinant Human Melanoma Antigen Family A， 1

英文简称:
MAGEA1

中文名称:
重组人黑素瘤抗原家族A， 1

背景资料:
Melanoma antigen family A 1 belongs to the MAGEA gene family， whose members encode proteins with 50 to 80% sequence identity to each other. The MAGEA genes which are clustered at chromosomal location Xq28， have bMAGE1 Human Recombinant full length protein expressed in E.coli， MAGE-1 is antibody reactive. The MAGE-1 is fused to a GST tag purified by proprietary chromatographic techniques.n implicated in some hereditary disorders， such as dyskeratosis congenita. Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous， tumor directed and specific， cytolytic， CD8+T lymphocyte clones （CTL）. An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens （MAAs）. Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types （melanoma， brain tumors of glial origin， neuroblastoma， non-small cell lung cancer， breast， gastric， colorectal， ovarian， renal cell carcinomas） and not on normal tissues， the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

产品描述:
MAGE1 Human Recombinant full length protein expressed in E.coli， MAGE-1 is antibody reactive. The MAGE-1 is fused to a GST tag purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
Sterile Filtered clear solution. MAGE-1 in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.

保存建议：
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。