重组人Ras同系物家族成员C

产品英文名称：
Recombinant Human Ras Homolog Enriched in Brain

英文简称:
RHEB

中文名称:
重组人富集于脑Ras同系物

背景资料:
RHEB is part of the Ras & GTPase superfamily that was originally identified as an immediate-early gene in brain but is also widely expressed in other tissues. RHEB encodes a lipid-anchored， cell membrane protein with five repeats of the RAS-related GTP-binding region. RHEB is necessary in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. RHEB has GTPase activity and shuttles betwRHEB Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 197 amino acids （1-181 amino acids） and having a molecular mass of 21.7 kDa. The RHEB is fused to T7-tag at N-terminus （16 a.a.） and is purified by standard chromatography techniques.n a GDP-bound form and a GTP-bound form， and farnesylation of the protein is required for this activity. RHEB induces oncogenic transformation. RHEB overexpression accelerates lymphomagenesis and is associated with prostate cancer. RHEB can cytopathologically distinguish betwRHEB Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 197 amino acids （1-181 amino acids） and having a molecular mass of 21.7 kDa. The RHEB is fused to T7-tag at N-terminus （16 a.a.） and is purified by standard chromatography techniques.n fibroadenoma from malignant breast carcinomas which is considered as a secondary diagnostic tool. RHEB has a central role in the regulation of the Ras/B-Raf/C-Raf/MEK signaling network.

产品描述:
RHEB Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 197 amino acids （1-181 amino acids） and having a molecular mass of 21.7 kDa. The RHEB is fused to T7-tag at N-terminus （16 a.a.） and is purified by standard chromatography techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MASMTGGQQM GRGSASMPQS KSRKIAILGY RSVGKSSLTI QFVEGQFVDS YDPTIENTFT KLITVNGQEY HLQLVDTAGQ DEYSIFPQTY SIDINGYILV YSVTSIKSFE VIKVIHGKLL DMVGKVQIPI MLVGNKKDLH MERVISYEEG KALAESWNAA FLESSAKENQ TAVDVFRRII LEAEKMDGAA SQGKSSC.

溶解建议:
Sterile Filtered colorless solution. The RHEB protein solution contains 20mM Tris pH-8， 1mM DTT and 10% glycerol.

保存建议：
RHEB although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。