重组人视黄酸受体应答蛋白2

产品英文名称：
Recombinant Human Retinoic Acid Receptor Responder 2

英文简称:
RARRES2

中文名称:
重组人视黄酸α受体

背景资料:
RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in a vast variety of tissues. RARRES2 acts as an adipokine， and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors， cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity， which requires proteolytic cleavage of its COOH-terminal domain to be exchangRARRES2 Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 138 amino acids and having a total molecular mass of 16 kDa. RARRES2 Human Recombinant is purified by proprietary chromatographic techniques.d into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor， ChemR23 （CMKLR1）， as a positive regulator of adipocyte di大肠杆菌中重组表达erentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. The Chemerin receptor has another ligand， called tazarotene-induced gene

产品描述:
RARRES2 Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 138 amino acids and having a total molecular mass of 16 kDa. RARRES2 Human Recombinant is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAAVDTP FPAGIFVRLE FKLQQTSRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS.

溶解建议:
Sterile Filtered White lyophilized （freeze-dried） powder. The RARRES2 protein was lyophilized from 0.02% TFA. It is recommended to reconstitute the lyophilized Chemerin in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.

保存建议：
Lyophilized Chemerin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Chemerin should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。