重组人Kirsten大鼠肉瘤病毒原癌基因蛋白

产品英文名称：
Recombinant Human KISS-1 Metastasis-Suppressor

英文简称:
KISS1

中文名称:
重组KISS-1肿瘤转移抑制蛋白

背景资料:
KISS1 is a metastasis suppressor protein that suppresses metastases of melanomas and breast carcinomas without a大肠杆菌中重组表达ecting tumorigenicity.KISS1 functions to inhibit chemotaxis and invasion， attenuating metastasis in malignant melanomas. KISS1 is involved in the regulation of cell-matrix adhesion. KISS1 plays a role in cytoskeletal reorganization. A polymorphism in the terminal exon of KISS1 mRNA results in two protein isoforms. Expression of KiSS1 is localized to specific regions of the hypothalamus in numerous species and is regulated by gonadal steroids and across the estrous cycle..KISS1 generates a c-terminally amidated peptide， metastin which functions as the endogenous ligand of the g-protein coupled receptor gpr54. Activation of the receptor inhibits cell proliferation and cell migration， key characteristics of tumor metastasis.

产品描述:
KISS1 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 120 amino acids （20-138） and having a molecular mass of 12.6 Dalton. The KISS1 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG.

溶解建议:
Sterile Filtered colorless solution. The protein solution （1mg/ml） contains 20mM Tris-HCl pH-8， 1mM DTT & 10% glycerol.

保存建议：
KISS1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。