重组人SMAD家族成员2

产品英文名称：
Recombinant Human Estrogen Receptor Alpha

英文简称:
ER-a

中文名称:
重组人雌激素受体α

背景资料:
Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding， DNA binding， and activation of transcription. Estrogen and its receptors are crucial for sexual development and reproductive function， but also play a role in other tissues such as bone. The Estrogen Receptor is a significant regulator of growth and di大肠杆菌中重组表达erentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer， endometrial cancer， and osteoporosis. The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）. The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains， named A - F. Alternative splicing results in a number of transcript variations， which di大肠杆菌中重组表达er in their 5’ UTRs and use di大肠杆菌中重组表达erent promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2.

产品描述:
ER ? Human Recombinant （a.a. 1-300） expressed in E.coli， shows a 59 kDa SDS-PAGE. The ER ? is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
Sterile Filtered clear solution. ER ? in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.

保存建议：
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。