重组人α-1抗胰蛋白酶

产品英文名称：
Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 1

英文简称:
EIF4EBP1

中文名称:
重组人真核翻译起始因子4E结合蛋白1

背景资料:
EIF4EBP1 （eukaryotic translation initiation factor 4E-binding protein 1） belongs to a family of translation repressor proteins. EIF4EBP1 regulates eIF4E （eukaryotic translation initiation factor 4E） activity by preventing its assembly into the eIF4F complex and mediates the regulation of protein translation by hormones， growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. EIF4EBP1 is phosphorylated in response to various signals including UV irradiation and insulin signaling， resulting in its dissociation from eIF4E and activation of mRNA translation. EIF4EBP1 C-terminus has domains which control function and phosphorylation. EIF4EBP1 has a role in progression of breast neoplasms through cell signaling.

产品描述:
EIF4EBP1 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 138 amino acids （1-118 a.a.） and having a molecular mass of 14.7 kDa. The EIF4EBP1 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MGSSHHHHHH SSGLVPRGSH MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI.

溶解建议:
Sterile Filtered colorless solution. The EIF4EBP1 solution contains 20mM Tris-HCl buffer （pH8.0） and 10% glycerol.

保存建议：
EIF4EBP1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。