重组人S100钙结合蛋白B，GST标签

产品英文名称：
Recombinant Human DNA Damage Inducible Transcript 3 GST tag

英文简称:
DDIT3 GST

中文名称:
重组人DNA损伤诱导转录因子3，GST标签

背景资料:
GADD 153 has bDDIT3 Human Recombinant full length protein fused to GST tag expressed in E.coli， shows a 52 kDa on SDS-PAGE. The DDIT3 is purified by proprietary chromatographic techniques.n described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression is induced by a variety of cellular stresses， including glucose deprivation， exposure to genotoxic agents， UV irradiation， the acute phase reaction， and other growth-arresting situations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from “classical” C/EBP binding sites， recognizing instead unique “nonclassical” sites. In growing cells gadd153 is expressed at very low levels. Cell cycle arrest might be induced by forced expression of gadd153 in numerous types of cells； it might also induce cell death by apoptosis. Myc protein strongly stimulates cellular proliferation by inducing cells to exit G0/G1 and enter the cell cycle. Myc protein represses the expression of gadd153. During the development of the brain CHOP pathway plays a role in neuronal apoptosis. There is consistent rearrangement of the gadd153 gene in myxoid liposarcomas. The fusion of CHOP with the neioring TLS gene creates TLS-CHOP which is a tumor-specific form of CHOP. This fusion fails to cause growth arrest and hinders with the ability of normal CHOP to induce growth arrest.

产品描述:
DDIT3 Human Recombinant full length protein fused to GST tag expressed in E.coli， shows a 52 kDa on SDS-PAGE. The DDIT3 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
Sterile Filtered clear solution. DDIT3 protein at a concentration 100ug/ml in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.

保存建议：
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。