重组人钙调磷酸酶1

产品英文名称：
Recombinant Human Chloride Intracellular Channel 1

英文简称:
CLIC1

中文名称:
重组人细胞内氯离子通道蛋白1

背景资料:
Chloride channels are various group of proteins that control fundamental cellular processes including stabilization of cell membrane potential， transepithelial transport， regulation of intracellular pH， and maintenance of cell volume. CLIC1 is part of the p64 family and is localized to the cell nucleus. CLIC1 displays both nuclear and plasma membrane chloride ion channel activity. CLIC1 inserts into membranes and forms chloride ion channels. CLIC1 channel activity depends on the pH. CLIC1 membrane insertion is redox-regulated and happens under oxydizing conditions.

产品描述:
CLIC1 Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 261amino acids （1-241a.a.） and having a molecular mass of 29 kDa. CLIC1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
来源宿主:
大肠杆菌中重组表达

序列:
GSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA SDDEEIE LAYEQVAKAL K.

溶解建议:
Sterile filtered colorless solution. CLIC1 Human solution containing 20mM Trsi HCL pH-8， 0.1M NaCl & 10% glycerol.

保存建议：
CLIC1 Human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。