重组人多聚腺苷酸结合蛋白相互作用蛋白1

产品英文名称：
Recombinant Human Complement Component 1

英文简称:
C1QBP

中文名称:
重组人补体1

背景资料:
C1QBP having the accession number of NP_001203 binds to the globular "heads" of c1q thus inhibiting c1 activation. C1QBP interacts with a wide range of ligands and is implicated in cell signaling. C1QBP associates with C1r and C1s in order to yield the first component of the serum complement system. C1QBP protein has bC1QBP Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 210 amino acids and having a molecular mass of 23.9 kDa.n identified as the p32 subunit of pre-mRNA splicing factor SF2， as well as a hyaluronic acid-binding protein. C1QBP is a new marker of tumor cells and tumor-associated macrophages/myeloid cells in hypoxic/metabolically deprived areas of tumors. Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells， and migration is mediated through ligation of both C1QBP and cC1qR/CR. C1QBP overexpression successfully blocks mRNA accumulation from the adenovirus major late transcription unit （MLTU） and stimulates RNA polymerase II carboxy-terminal domain phosphorylation in virus-infected cells. C1QBP binds with Hepacivirus core protein on CD8+ and CD4+ positive t-cells and inactivates lck and akt.

产品描述:
C1QBP Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 210 amino acids and having a molecular mass of 23.9 kDa.
来源宿主:
大肠杆菌中重组表达

序列:
MLHTDGDKAF VDFEIKE ERKIQKHKTL PKMSGGWELE LNGTEAKLVR KVAGEKITVT FNINNSIPPT FDGEEEPSQG QKVEEQEPEL TNFVVEV IKNDDGKKAL VLDCHYPEDE VGQEDEAESD IFSIREVSFQ STGESEWKDT NYTLNTDSLD WALYDHLMDF LADRGVDNTF ADELVELSTA LEHQEYITFL EDLKSFVKSQ.

溶解建议:
Sterile Filtered colorless solution. The C1QBP protein solution contains 20mM Tris-HCl pH7.5， 20% glycerol and 1mM DTT.

保存建议：
C1QBP although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。