重组人SUMO/sentrin特异性肽酶8

产品英文名称：
Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform

英文简称:
ADAM12

中文名称:
重组人ADAM12

背景资料:
ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins， and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions， including fertilization， muscle development， and eurogenesis. ADAM12 has 2 alternatively spliced transcripts， a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta， embryo and foetus although levels have bADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single， non-glycosylated polypeptide chain containing 531 amino acids （208-738） and having a molecular mass of 62 kDa.n detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration， specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells （MGC） and osteoclast formation from mononuclear precursors （by similarity）.

产品描述:
ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single， non-glycosylated polypeptide chain containing 531 amino acids （208-738） and having a molecular mass of 62 kDa.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
Sterile Filtered colorless solution. The ADAM12 solution contains 20mMTris HCl and 50% Glycerol.

保存建议：
ADAM12 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

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