KIR2DS4

产品英文名称：
Recombinant Human Killer Cell Immunoglobulin-Like Receptor， 2 Domains Short Cytoplasmic Tail 4

英文简称:
KIR2DS4

中文名称:
重组人杀伤细胞免疫球蛋白样受体， 双域 短细胞质尾4

背景资料:
Killer-cell immunoglobulin-like receptors （KIRs）， are a family of cell surface glycoproteins found on Natural Killer （NK） Cells， which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules， which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory， which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex （LRC）. KIR molecules are extremely polymorphic， meaning their gene sequences di大肠杆菌中重组表达er significantly betwRecombinant KIR2DS4 produced in E.Coli is a single， non-glycosylated polypeptide chain containing amino acids 1-202 and having a molecular mass of 22.2 kDa. The KIR2DS4 is purified by proprietary chromatographic techniques.n individuals， so that di大肠杆菌中重组表达erent individuals have di大肠杆菌中重组表达erent arrays/repertoires of KIR genes. The KIR proteins are categorized by the number of extracellular immunoglobulin domains （2D or 3D） and by whether they have a long （L） or short （S） cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif （ITIM）. Whereas KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR2DS4 is an activating Killer Cell Ig-like Receptor （KIR， previously called p50 KIR， p50.3， cl39， or KAR-K1）， which may recognize class I MHC molecules. KIR2DS4 does not inhibit the activity of NK cells.

产品描述:
Recombinant KIR2DS4 produced in E.Coli is a single， non-glycosylated polypeptide chain containing amino acids 1-202 and having a molecular mass of 22.2 kDa. The KIR2DS4 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MEGVHRKPSF LALPGHLVKS EETVILQCWS DVMFEHFLLH REGKFNNTLH LIGEHHDGVS KANFSIGPMM PVLAGTYRCY GSVPHSPYQL SAPSDPLDMV IIGLYEKPSL SAQPGPTVQA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAVRSINGTF QADFPLGPAT HGGTYRCFGS FRDAPYEWSN SSDPLLVSVT GN.

溶解建议:
Sterile filtered colorless solution. The protein （1mg/ml） contains 20mM Tris-HCl （pH-7.5）.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles.
其他简介：

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