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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
2-8°C
- 保质期:
1年
- 英文名:
PRNP
- 库存:
999
- 供应商:
南京赛泓瑞
- 规格:
/5ug/20ug/1mg
Recombinant Human Fibrinogen
英文简称:
Fibrinogen
中文名称:
重组人纤维蛋白原
背景资料:
Fibrinogen is a blood-borne glycoprotein comprised of 3 pairs of nonidentical polypeptide chains. Fibrinogen is disulfide linked heterohexamer, which contains 2 sets of 3 non-identical chains (alpha, beta and gamma). Subsequent to vascular injury, fibrinogen is cleaved by thrombin to make fibrin which is the most abundant component of blood clots. Furthermore, di人胚肾HEK细胞重组表达erent cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, exhibit vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Therefore, Fibrinogen has a double function: yielding monomers that polymerize into fibrin and functioning as a cofactor in platelet aregation.
产品描述:
Recombinant Human Fibrinogen produced in HEK cells is comprised from the Aa chain (ACC# P02671), Bb chain (ACC# P02675) and g chain (ACC# P02679), having a total molecular weight of 340kDa. The Fibrinogen is purified by proprietary chromatographic techniques.
来源宿主:
人胚肾HEK细胞重组表达
序列:
溶解建议:
提供的重组人纤维蛋白原产品形式为经无菌过滤处理的无色溶液.
保存建议:
重组人纤维蛋白原产品在于-20°C 到-80°C 长期保存.避免反复冻融.
其他简介:
ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列,专注于蛋白(重组及合成)生产研发,其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子,生长因子,激素,信号蛋白,病毒抗原等近800种重组蛋白和100多种抗体,是世界上提供蛋白品种最多的公司之一,领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。
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文献和实验linaque 本人没做过RNA干扰,想请教一个问题,可以在整体动物上沉默某个基因的表达吗?还是只能在细胞水平沉默某基因的表达?还是说在整体水平若要沉默某基因只能通过敲基因的方法?谢谢! 路得自己走 基于过表达miRNA(当siRNA用了)的转基因小鼠敲减Prnp的实验,不知是否符合楼主所说的。 linaque 谢谢! kinguangjun 个人
Prions: From Neurografts to Neuroinvasion
have contributed many important insights to the field of prion biology. The prion protein (PrPC ) is encoded by the Prnp gene, and disruption of Prnp leads to resistance to infection by prions. Ectopic expression of PrPC in PrPC -knockout mice proved a useful tool
A Function for the Prion Protein
. 1 -3 ), concentrated on the characterization of the infectious agent, and led to the introduction of the term “prion” in 1982 (4 ). But it was not until the positive association of the infectious agent, PrPSc, with a normal host gene locus, prnp , that real
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