PDCD6

产品英文名称：
Recombinant Human Tumor Susceptibility Gene 101

英文简称:
TSG101

中文名称:
重组人肿瘤易感基因101

背景资料:
TSG101 is a member of apparently inactive homologs of ubiquitin-conjugating enzymes. TSG101 contains a coiled-coil domain that interacts with stathmin， a cytosolic phosphoprotein implicated in tumorigenesis. TSG101 is involved in cell growth and di大肠杆菌中重组表达erentiation and acts as a negative growth regulator. TSG101 in vitro steady-state expression is important for maintenance of genomic stability and cell cycle regulation. TSG101 mutations and alternative splicing occur in high rate in breast cancer and implicate that defects occur during breast cancer tumorigenesis and/or progression. TSG101 is a factor of the ESCRT-I complex， a monitor of vesicular tra大肠杆菌中重组表达icking process. TSG101 binds to ubiquitinated cargo proteins and is nTSG101 Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 181 amino acids （1-145 a.a.） and having a molecular mass of 20.7 kDa. TSG101 protein is fused to a 36 amino acid His-Tag at N-terminus and purified by standard chromatography.ded for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. TSG101 is nTSG101 Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 181 amino acids （1-145 a.a.） and having a molecular mass of 20.7 kDa. TSG101 protein is fused to a 36 amino acid His-Tag at N-terminus and purified by standard chromatography.ded for completion of cytokinesis and is involved in cell growth and di大肠杆菌中重组表达erentiation.

产品描述:
TSG101 Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 181 amino acids （1-145 a.a.） and having a molecular mass of 20.7 kDa. TSG101 protein is fused to a 36 amino acid His-Tag at N-terminus and purified by standard chromatography.
来源宿主:
大肠杆菌中重组表达

序列:
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAVS ESQLKKMVSK YKYRDLTVRE TVNVITLYKD LKPVLDSYVF NDGSSRELMN LTGTIPVPYR GNTYNIPICL WLLDTYPYNP PICFVKPTSS MTIKTGKHVD ANGKIYLPYL HEWKHPQSDL LGLIQVMIVV FGDEPPVFSR P.

溶解建议:
Sterile filtered colorless solution. TSG101 Human solution containing 20mM Trsi HCL pH-8， 1mM DTT and 10% glycerol.

保存建议：
TSG101 human although stable at 4
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。