NDE1

产品英文名称：
Recombinant Human Triering Receptor Expressed on Myeloid Cells 1

英文简称:
TREM1

中文名称:
重组人髓样细胞触发性受体-1

背景资料:
TREM1 is a transmembrane receptor protein that is involved in monocytic activation and in the inflammatory response. TREM1 is expressed on the surface of neutrophils， mature monocytes and macrophages. TREM1 stimulates neutrophil and monocyte-mediated inflammatory responses. TREM1 also triers the release of pro-inflammatory chemokines and cytokines， as well as increased surface expression of cell activation markers. Furthermore， TREM1 is an amplifier of inflammatory responses that are triered by bacterial and fungal infections and is a fundamental mediator of septic shock. The expression of the soluble form of TREM1 increases during sepsis and can consequently be used as a biological marker for septic shock. TREM1 is strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Increased TREM1 expression on monocytes is related to both infectious and noninfectious inflammatory processes. TREM1 is vastly expressed in adult liver， lung and splTREM1 Human Recombinant produced in E.Coli is single， a non-glycosylated， Polypeptide chain containing 180 amino acids fragment （21-200） corresponding to mature soluble extracellular domain fragment of TREM-1， having a total molecular mass of 24.76kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TREM1 is purified by proprietary chromatographic techniques.n than in corresponding fetal tissue. TREM1 is also expressed in the lymph node， placenta， spinal cord and heart tissues. TREM1 expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. TREM1 is expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes.

产品描述:
TREM1 Human Recombinant produced in E.Coli is single， a non-glycosylated， Polypeptide chain containing 180 amino acids fragment （21-200） corresponding to mature soluble extracellular domain fragment of TREM-1， having a total molecular mass of 24.76kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TREM1 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
Sterile Filtered clear solution. TREM1 protein is supplied in 10mM BTP pH-9， 75mM NaCl and 50% glycerol.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. Please avoid freeze thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。