ALDH5A1

产品英文名称：
Recombinant Human Aldehyde Dehydrogenase 5 A1

英文简称:
ALDH5A1

中文名称:
重组人琥珀酸半醛脱氢酶

背景资料:
ALDH5A1 is a mitochondrial NAD（+)-dependent succinic semialdehyde dehydrogenase， which is a member of the aldehyde dehydrogenase family of proteins. The ALDH5A1 protein functions as a mediator to the NADP+-dependent oxidation of aldehydes into acids and has an imperative role in the detoxification of alcohol-derived acetaldehyde， as well as in lipid peroxidation and in the metabolism of corticosteroids， biogenic amines and neurotransmitters. ALDH5A1 is expressed in various tissues， including the liver， heart， lung， brain， kidney and placenta. Deficiency in the ALDH5A1 enzyme， known as 4-hydroxybutyricaciduria， is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid（GABA). In response to this defect， physiologic fluids from patients accumulate GHB， which is a compound with numerous neuromodulatory properties.

产品描述:
inant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 509 amino acids（48-535 a.a.) and having a molecular mass of 54.6kDa. The ALDH5A1 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MGSSHHHHHH SSGLVPRGSH MAGRLAGLSA ALLRTDSFVG GRWLPAAATF PVQDPASGAA LGMVADCGVR EARAAVRAAY EAFCRWREVS AKERSSLLRK WYNLMIQNKD DLARIITAES GKPLKEAHGE ILYSAFFLEW FSEEARRVYG DIIHTPAKDR RALVLKQPIG VAAVITPWNF PSAMITRKVG AALAAGCTVV VKPAEDTPFS ALALAELASQ AGIPSGVYNV IPCSRKNAKE VGEAICTDPL VSKISFTGST TTGKILLHHA ANSVKRVSME LGGLAPFIVF DSANVDQAVA GAMASKFRNT GQTCVCSNQF LVQRGIHDAF VKAFAEAMKK NLRVGNGFEE GTTQGPLINE KAVEKVEKQV NDAVSKGATV VTGGKRHQLG KNFFEPTLLC NVTQDMLCTH EETFGPLAPV IKFDTEEEAI AIANAADVGL AGYFYSQDPA QIWRVAEQLE VGMVGVNEGL ISSVECPFGG VKQSGLGREG SKYGIDEYLE LKYVCYGGL.

溶解建议:
提供的重组人琥珀酸半醛脱氢酶产品形式为无菌的无色溶液.

保存建议：
人琥珀酸半醛脱氢酶蛋白产品可整瓶4℃保存2-4周，长期保存请置于-20℃.推荐添加载体蛋白（0.1% HSA或BSA)以长期保存，请避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。