TSH

产品英文名称：
Recombinant Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera

英文简称:
VEGFR2 Fc

中文名称:
重组人血管内皮生长因子受体-2 Fc嵌合体

背景资料:
Endothelial cells express thrSoluble VEGFR-2 Fc Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a disulfide-linked homodimeric， glycosylated， polypeptide containing 757 amino acids and having a molecular mass of 160 kDa. The soluble receptor protein contains only the first 7 extracellular domains， which contain all the information necessary for ligand binding. The sKDR Fc Chimera is purified by proprietary chromatographic techniques. di昆虫细胞中重组表达erent vascular endothelial growth factor （VEGF） receptors， belonging to the family of receptor tyrosine kinases （RTKs）. They are named VEGFR-1 （Flt-1）， VEGFR-2 （KDR/Flk-1）， VEGFR-3 （Flt-4）. Their expression is almost exclusively restricted to endothelial cells， but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains， a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower a昆虫细胞中重组表达inity for VEGF than the Flt-1 receptor， but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. Di昆虫细胞中重组表达erential splicing of the flt-1 gene leads to the formation of a secreted， soluble variant of VEGFR-1 （sVEGFR-1）. No naturally occuring， secreted forms of VEGFR-2 have so far bSoluble VEGFR-2 Fc Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a disulfide-linked homodimeric， glycosylated， polypeptide containing 757 amino acids and having a molecular mass of 160 kDa. The soluble receptor protein contains only the first 7 extracellular domains， which contain all the information necessary for ligand binding. The sKDR Fc Chimera is purified by proprietary chromatographic techniques.n reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin.

产品描述:
Soluble VEGFR-2 Fc Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a disulfide-linked homodimeric， glycosylated， polypeptide containing 757 amino acids and having a molecular mass of 160 kDa. The soluble receptor protein contains only the first 7 extracellular domains， which contain all the information necessary for ligand binding. The sKDR Fc Chimera is purified by proprietary chromatographic techniques.
来源宿主:
昆虫细胞中重组表达

序列:


溶解建议:
提供的人血管内皮生长因子受体-2 Fc嵌合体（VEGFR2 Fc）产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1mg/ml人血管内皮生长因子受体-2 Fc嵌合体（VEGFR2 Fc）的1x PBS pH 7.4溶液中过滤灭菌并冻干产生的.我们建议加无菌水以配制工作储存液到不低于100ug/ml，后继实验过程中可根据实验要求进一步稀释.

保存建议：
人血管内皮生长因子受体-2 Fc嵌合体（VEGFR2 Fc）冻干粉末在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天以上；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存.请避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。