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EMT inhibitor-1
CAS No. : 1638526-21-2
MCE 国际站：EMT inhibitor-1
产品活性：EMT inhibitor-1 是 Hippo，TGF-β 和 Wnt 信号通路的抑制剂，并拥有抗肿瘤活性。
研究领域：Stem Cell/Wnt | TGF-beta/Smad
作用靶点：Hippo (MST) | TGF-beta/Smad | Wnt
In Vitro: EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.
In Vivo: EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).
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文献和实验Functional Analysis of CDK Inhibitor p21WAF1
p21WAF1 was originally identified as a protein that binds and inhibits cyclin-dependent kinases (CDKs). p21WAF1 is recognized to have at least two separate roles—first as a CDK inhibitor, and second as an inhibitor of PCNA, an accessory
Analysis of EMT by Flow Cytometry and Immunohistochemistry
Ovarian cancer stem cells (OCSCs) are in a transitional phase between epithelial and mesenchymal cell stages. Consequently, OCSCs possess a high degree of plasticity that complicates their identification and characterization
beebeeliang 大家好！最近我在做EMT 方面的研究，遇到一些问题，请大家给点意见。 在TGFb诱导细胞EMT的试验中，有的文章是在无血清培养基中进行的，有的则是在10％FBS培养基中进行的。相信大家看文章都会发现这一点。不知两者有何利弊？请高手分析一下！万分感激。 zfv2007 其实大多数TGFb诱导EMT实验中，所谓的无血清培养基都是包含0.5%FBS的培养基。严格的EMT
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